Hello, Max 👋

Parkinson's is twice as likely in men than in women and 85% of that risk is due to environmental factors. Studies have linked pesticide exposure to increased risk of Parkinson's and also to pre-Parkinson's. Signs of pre-Parkinson's are slower walking speed, stiff joints, unsteady gait, and mild hand tremors. Filtering your drinking water and thoroughly washing your produce can reduce your risk of Parkinson's and pre-Parkinson's.

Your genetic testing indicates that you have at least one MTHFR variant, which increases homocysteine levels and decreases folate. High levels of homocysteine are associated with increased risk of a variety of conditions including stroke, depression, and cardiovascular disease. Folic acid (Vitamin B9) supplementation can reduce homocysteine levels by up to 25%.

Your genetic testing indicates that you have at least one MTHFR variant, which increases homocysteine levels and decreases folate. High levels of homocysteine are associated with increased risk of a variety of conditions including stroke, depression, and cardiovascular disease. Folic acid (Vitamin B9) supplementation or increased dietary folate intake can reduce homocysteine levels by up to 25%. We recommend that you track your homocysteine and folate levels to ensure that you are within normal range.

Your testing indicates that sleep is one of your top two lifestyle areas to improve. Having trouble with sleep is extremely common. It is important to work on because having poor sleep puts you at higher risk for Alzheimer's and Cardiovascular Disease. We've put together an article outlining strategies for a better night's sleep. These strategies include better sleep habits, supplements, and some newer medications that may be helpful.

1. Your NeuroAge is not fully optimized. This puts you at higher risk for Alzheimer’s and white matter hyperintensities. Omega-3 fatty acid supplementation is particularly helpful for preventing dementia and decreasing white matter hyperintensities. 2. Your genetic testing indicates that you have at least one copy of the APOE4 variant. This puts you at higher risk for Alzheimer’s and white matter hyperintensities. Omega-3 fatty acid supplementation is particularly helpful for preventing dementia and decreasing white matter hyperintensities especially for people with APOE4 variants.

Your hippocampal volume is not fully optimized for your age and sex. The hippocampus is main the brain area affected in Alzheimer’s disease, and having a larger hippocampal volume decreases future risk of Alzheimer’s

Your testing indicates that sleep or stress are in your top two lifestyle areas to improve. A small study showed that sleep, stress, and blood cortisol levels improved with ashwaganda supplementation. Please note that ashwaganda is contraindicated in pregnant women and men with hormone-sensitive prostate cancer. It may have some drug-drug interactions and it may lower your blood pressure and/or your blood glucose. Always ensure that your supplements are third party tested for purity and dosage to avoid harmful contaminants and incorrect dosing.

Your NeuroGames scores indicate that your memory and/or focus is not fully optimized. You may be able to improve your memory and focus with curcumin-turmeric supplementation(ref)

Your memory is not fully optimized. Lion’s Mane mushroom supplementation enhanced recognition memory in a study in mice. It also increased lifespan by 23% in male mice and 14% in female mice. The studies in humans are small and scant, which is why we labeled this recommendation "emerging evidence". However the data we do have in humans is mostly positive for improving memory. Lion’s Mane is delicious and tastes mildly of seafood. You can purchase it at a specialty grocery store, forage it, grow it at home, or take it as a supplement (2g/day). We strongly advise purchasing supplements that have been third party tested for purity and quantity.

Your genetic testing indicates that you do not have a protective FOXO3 bonus longevity variant. You may be able to increase your FOXO3 levels through exercise and through EGCG supplementation.